The western part of Anatolia is one of the most seismically and tectonically active continental regions in the world, and much of it has been undergoing NS-directed extensional deformation since the Early Miocene. In this study, we determine 3-D tomographic images of the crust under the southwestern part of the North Anatolian Fault Zone by inverting a large number of arrival time data of P and S waves. From the obtained P- and S-wave velocity models, we estimated the Poisson's ratio structures for a more reliable interpretation of the obtained anomalies. Our tomographic results confirmed the major tectonic features detected by previous studies and revealed new structural heterogeneities related to the active seismotectonics of the studied area. High P-wave velocity anomalies are recognized near the surface, while at deeper crustal layers, low P-wave velocities are widely distributed. The crustal S-wave velocity and Poisson's ratio exhibit more structural heterogeneities compared to the P-wave velocity structure. Microearthquake activity is intense along highly heterogeneous zones in the southwestern part, which is characterized by low to high P-wave velocity, low S-wave velocity, and high Poisson's ratio anomalies. Large earthquakes are also concentrated in zones dominated by low velocities and low to high Poisson's ratios. Results of the checkerboard and synthetic tests indicate that the imaged anomalies are reliable features down to a depth of 25 km. Moreover, they are consistent with many geological and geophysical results obtained by other researchers along the southwestern part of the North Anatolian Fault Zone.