Izmir, the third largest city and one of the major economic centers in Turkey, has more than three million residents and one-half million buildings. The city, located in a seismically active region in western Anatolia, was a subject of the 1997 RADIUS (Risk Assessment Tools for Diagnosis of Urban Areas against Seismic Disaster) project. In this paper, the seismic hazard of Izmir is investigated through probabilistic seismic hazard assessment. First, the seismic setting of Izmir is presented. Considering the statistics of earthquakes that took place in the region during the period 1900-2005, a simple seismic hazard model is used to facilitate the assessment. To account for modeling uncertainties associated with the values of seismicity parameters, a logic tree procedure is employed in carrying out the seismic hazard computations. The resulting weighted average seismic hazard, presented in terms of peak ground acceleration and associated probability of exceedence, could be considered the "best estimate" of seismic hazard for Izmir. Accordingly, for a return period of 475 years, for rock sites, a PGA value of 0.34 g is calculated. This PGA hazard estimate is close to the current code-recommended design acceleration level for Izmir.