In this study, lead of heavy metal was applied one month to California red worm (Eisenia foetida) in order to identify damage of lead accumulation in the soil. 36 adult California red worms (Eisenia foetida) were used. The first group was control group, the second group was applicated the daily 200 ppm lead standard and the third group was applicated lead standard and broccoli in the medium. Histopathological estimation of control group in skin tissue was not observed degeneration. The daily 200 ppm lead standard applicated the second group histopathological evaluation was observed cellular atrophy which shrinking the volume of epidermis cells and necrotic cells which losing the nuclei. Lymphocytic infiltration was detected at the dermis densely. Broccoli+lead applicated in group 3, where in the epidermal cells were detected swollen and vacuolated unlike the group 2. Especially, accretion and hypertrophy in goblet cell was greater. Cellular degeneration or injury was not observed in the dermis layer.