Iron oxide/poly(3,4-ethylenedioxythiophene): poly(styrene sulfonate) glassy carbon electrode as a novel label-free electrochemical microRNA-21 sensor
Instrumentation Science and Technology, vol.52, no.1, pp.67-79, 2024 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 52 Issue: 1
- Publication Date: 2024
- Doi Number: 10.1080/10739149.2023.2221339
- Journal Name: Instrumentation Science and Technology
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Biotechnology Research Abstracts, Chemical Abstracts Core, Compendex, INSPEC
- Page Numbers: pp.67-79
- Keywords: 4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS), cyclic voltammetry (CV), electrochemical biosensor, glassy carbon electrode (GCE), Iron oxide, microRNA-21 (miRNA-21), poly(3
- Süleyman Demirel University Affiliated: Yes
Abstract
MicroRNAs (miRNAs), a type of non-protein-coding and small RNAs, are encouraging molecular biomarkers for prior diagnosis of the certain diseases. Here, an electrochemical sensor based on iron oxide/poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate (Fe3O4/PEDOT:PSS) hybrid coated glassy carbon electrode (GCE) is reported to determine microRNA-21 (miRNA-21) as a biosensing platform based on hybridization event. The biosensor was characterized by cyclic voltammetry (CV) measurements. The Fe3O4/PEDOT:PSS demonstrated good sensing performance, including a wide detection range (0.1 pM-1 µM) and a low detection limit (0.023 pM) for potential medical applications.