Modulation of Salubrinal-Mediated Endoplasmic Reticulum Stress in an Experimental Subarachnoid Hemorrhage Model
WORLD NEUROSURGERY, cilt.153, 2021 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 153
- Basım Tarihi: 2021
- Doi Numarası: 10.1016/j.wneu.2021.07.005
- Dergi Adı: WORLD NEUROSURGERY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, Index Islamicus, MEDLINE, Veterinary Science Database
- Anahtar Kelimeler: Apoptosis, Endoplasmic reticulum, Eukaryotic translation initiation factor-2 alpha, Inflammation, Oxidative stress, Subarachnoid hemorrhage, UNFOLDED PROTEIN RESPONSE, EARLY BRAIN-INJURY, APOPTOSIS, DEPHOSPHORYLATION, NEUROPROTECTION
- Süleyman Demirel Üniversitesi Adresli: Evet
Özet
BACKGROUND: Perfusion abnormalities due to vasospasm remain a major cause of morbidity and mortality in subarachnoid hemorrhage (SAH). Despite a large number of clinical trials, therapeutic options with strong evidence for prevention and treatment of cerebral vasospasm are rare. In this study, we aimed to evaluate the neuroprotective effect of salubrinal (SLB) in endoplasmic reticulum stress-induced apoptosis, a catastrophic consequence of vasospasm.