Matrix Metalloproteinases (MMP-2 and MMP-9) and cyclooxygenase-2 (COX-2) expressions in vocal fold polyps.


KARAHAN N. , Baspinar Ş. , Yariktas M., Kapucuoglu N.

Journal of voice : official journal of the Voice Foundation, vol.23, no.1, pp.29-33, 2009 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 1
  • Publication Date: 2009
  • Doi Number: 10.1016/j.jvoice.2007.05.005
  • Title of Journal : Journal of voice : official journal of the Voice Foundation
  • Page Numbers: pp.29-33

Abstract

The objective Of this Study was to investigate the roles of matrix metalloproteinases (MMP-2, MMP-9) and cyclooxygenase-2 (COX-2) in the pathogenesis of vocal fold polyps (VFPs). Ill this study, 20 VFPs and 8 normal vocal fold (VF) specimens were obtained from subjects undergoing surgery. Staining intensities were semiquantitatively assessed and statistically analyzed. Significant increases were observed ill the expressions of MMP-2, MMP-9. and COX-2 ill stromal spindle cells (P = 0.00) and vascular wall (P = 0.04, P = 0.00, P = 0.00) of VFPs compared with normal VFs. MMP-2 expression ill surface epithelium basal cells (P = 0.00) of VFPs showed enhancement compared with normal vocal folds. whereas MMP-9 and COX-2 expressions showed no significant differences. Our study showed that gelatinases and COX-2 may play a role in the development of VFPs, This is the first Study to document the expression Of gelatinases and COX-2 in VFPs.