Association of inflammation with atrial fibrillation in hyperthyroidism

Ozaydin M. , KUTLUCAN A., Turker Y. , KOROGLU B., ARSLAN A., UYSAL B. A. , ...More

JOURNAL OF GERIATRIC CARDIOLOGY, vol.9, no.4, pp.344-348, 2012 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 4
  • Publication Date: 2012
  • Doi Number: 10.3724/sp.j.1263.2012.06251
  • Page Numbers: pp.344-348


Objectives The aim of this study was to evaluate the relationship between inflammation and development of atrial fibrillation (AF) in patients with hyperthyroidism. Methods A total of 65 patients with newly diagnosed hyperthyroidism, 35 of whom were in sinus rhythm and 30 of whom in AF. Thirty five age-and gender-matched patients in a control group were included in the study. Factors associated with the development of AF were evaluated by multivariate regression analysis. Results Factors associated with AF in multivariate analysis included high sensitivity C reactive protein (HsCRP) [odds ratio (OR): 11.19; 95% confidence interval (95% CI): 1.80-69.53; P = 0.003], free T4 (OR: 8.76; 95% CI: 2.09-36.7; P = 0.003), and left atrial diameter (OR: 1.25; 95% CI: 1.06-1.47; P = 0.008). Conclusions The results of the present study suggest that HsCRP, an indicator of inflammation, free T4 and left atrial diameter are associated with the development AF in patients with hyperthyroidism. J Geriatr Cardiol 2012; 9: 344-348. doi: 10.3724/SP.J.1263.2012.06251