Complications of metabolic acidosis and alkalinizing therapy in chronic kidney disease patients: a clinician-directed organ-specific primer


Copur S., Sag A. A. , AFŞAR B. , Rossignol P., Covic A., Kanbay M.

INTERNATIONAL UROLOGY AND NEPHROLOGY, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume:
  • Publication Date: 2020
  • Doi Number: 10.1007/s11255-020-02563-2
  • Title of Journal : INTERNATIONAL UROLOGY AND NEPHROLOGY

Abstract

Chronic kidney disease is prevalent, affecting more than one in ten adults. In this population, metabolic acidosis is considered a key underlying pathophysiological feature, tying together bone mineral disorders, sarcopenia, insulin resistance, vascular calcification, pro-inflammatory and pro-thrombotic states. This review aims to address the paucity of literature on alkalinizing agents, a promising treatment option that has known adverse effects.