ACUTE EFFECT OF FLAXSEED ON COLON TISSUE IN RATS


Özgöçmen M.

2. ULUSLARARASI SAĞLIK BİLİMLERİ VE YAŞAM KONGRESİ , Burdur, Turkey, 24 - 27 March 2019, pp.1426-1434

  • Publication Type: Conference Paper / Full Text
  • City: Burdur
  • Country: Turkey
  • Page Numbers: pp.1426-1434

Abstract

Flaxseed is a single-year culture plant and is usually grouped as functional food, bioactive food or endocrine active food. Nowadays, more than 50g of flaxseed can be consumed in addition to nutrients. While the studies are generally directed to the positive effect of flaxseed, some studies suggest that flaxseed may be toxic. The colon is the large intestine of the digestive system that separates water and minerals from the food and stores the rest for expulsion. Colon cancer is the fourth most common cancer in terms of its incidence. In recent years, herbal therapies for colon cancer are preferred. Flaxseed is one of the most important of these plants. Generally, the studies on flaxseed are long lasting and have a positive effect on colon cancer. In our study, we wanted to examine the effect of short-term and overuse flaxseed. In our study, 32 female Wistar rats were used; Group I; control (n: 8), Group II (low-dose flaxseed group; 1.4mg / g flaxseed gavage daily for 7 days), Group III (medium-dose flaxseed group; 2,8 mg / g flaxseed gavage every day for 7 days) Group IV (High-dose flaxseed group; 5.6mg / g flaxseed each day for 7 days) and was grouped. At the end of the experiment, the colon tissue was taken by histochemical analysis and stained with H-E and examined under a microscope. No histopathological findings were observed in the control group and no significant histopathological findings were found in the flaxseed groups compared to the control group. In conclusion, flaxseed did not cause significant damage to the colon tissue in the case of short-term consumption. In this sense, we believe that our study will lead other studies for time and dose of the experiments