Microwave synthesis of benzothiazolone-2(3h)-3-acetyl-2-(substitue/nonsubstitueindol or pyridine)hydrazone derivatives

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Arslan G., Önkol T., Özçelik A. B.

GPSS 2021, Ankara, Türkiye, 8 - 10 Eylül 2021, ss.57, (Özet Bildiri)

  • Yayın Türü: Bildiri / Özet Bildiri
  • Basıldığı Şehir: Ankara
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.57
  • Süleyman Demirel Üniversitesi Adresli: Evet

Özet

Schiff bases are compounds formed by the nucleophilic addition reaction of primary amines with the activated carbonyl group of aldehydes or ketones and contain carbon-nitrogen double bonds (-C=N-) [1]. Some studies have shown that the presence of an electron pair in an sp2 hybridized orbital of the nitrogen atom of Schiff bases is of great chemical and biological importance. In addition, these compounds are excellent metal chelators, especially when bound to functional groups such as - OH or - SH [2]. Schiff bases are not only easy to synthesize, but also find wide application in medicinal chemistry and the pharmaceutical industry, which has increased importance of these compounds [3]. In addition, Schiff bases showed antimicrobial [4], antiviral [4], antinociceptive [5], antiplatelet [5], antiproliferative [4,5], anticancer [4,5], and anticonvulsant [4,5] activities. Benzothiazolone is bicylic ring system of pharmaceutical importance due to its strong and important biological effects. In this study, new schiff base of Benzothiazolone-2(3H)-3-ilacetohyrazid derivates with substitue/nonsubstitueindol or substituepyridine aldehydes have been microwave synthesized. Structures of the synthesized compounds were verified by 1 H-NMR and LC-MS spectrospy methods