The oocyte quality and follicular fluid lipid peroxidation and antioxidant levels in the patients undergoing in vitro fertilization treatment
Journal of Cellular Neuroscience and Oxidative Stress, cilt.17, sa.1, ss.1245-1251, 2025 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 17 Sayı: 1
- Basım Tarihi: 2025
- Doi Numarası: 10.37212/jcnos.1630887
- Dergi Adı: Journal of Cellular Neuroscience and Oxidative Stress
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.1245-1251
- Anahtar Kelimeler: Embryo quality, Follicular fluid, In vitro fertilization, Lipid peroxidation, Oocyte quality, Vitamin E
- Süleyman Demirel Üniversitesi Adresli: Evet
Özet
This study aimed to compare demographic, embryological, and biochemical parameters between male factor infertility and unexplained infertility groups undergoing IVF treatment. Demographic parameters such as age and (BMI, along with embryological factors including the number of oocytes retrieved, MII oocytes, fertilization rate, and Grade II embryo quality, were evaluated. Biochemical markers, including MDA, GSH, GSH-Px, vitamin A, vitamin E, and ß-carotene, were also analyzed. No significant differences were observed between the two groups regarding demographic or embryological outcomes (p > 0.05), although Grade I embryo quality showed a significant difference (p = 0.047), underscoring the importance of embryo quality in IVF success. The clinical pregnancy and live birth rates were higher in the control group, but the differences were not statistically significant. Further biochemical analysis revealed significantly higher MDA levels in the patient group, indicating increased oxidative stress (p < 0.001). Conversely, antioxidant levels, including GSH, GSH-Px, vitamin A, and vitamin E, were found to be lower in the patient group, suggesting a weakened defense against oxidative stress. In conclusion, this study emphasizes the importance of managing oxidative stress through antioxidant levels to potentially improve IVF success rates.