In this study, precise, sensitive and accurate spectrophotometric-chemometric methods were developed for the Alzheimer's drugs in pharmaceutical tablets. The examined Alzheimer's drugs are donepezil and rivastigmine. The used chemometric methods are partial least squares regression (PLS) and principal component regression (PCR). PLS and PCR were successfully applied for chemometric analysis of donepezil and rivastigmine in synthetic mixtures and pharmaceutical tablets. A concentration set including binary mixtures of donepezil and rivastigmine formed to 10 different combinations were randomly prepared in 0.1 M HCl. The accuracy and precision of the developed method were validated by analyzing synthetic mixtures containing the examined drugs. As a result of the determination, high recoveries and low standard deviations were found. Absorbance and concentration values were used in Minitab and other chemometric programs to calculate estimated concentrations with PCR and PLS. The second step, in drug tablets (Exelon and Doenza), was calculated amounts for donepezil and rivastigmine.