A review on synthesis and biomedical applications of polyglycolic acid


Budak K., SÖĞÜT O., AYDEMİR SEZER Ü.

JOURNAL OF POLYMER RESEARCH, vol.27, no.8, 2020 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Review
  • Volume: 27 Issue: 8
  • Publication Date: 2020
  • Doi Number: 10.1007/s10965-020-02187-1
  • Journal Name: JOURNAL OF POLYMER RESEARCH
  • Journal Indexes: Science Citation Index Expanded, Scopus, Academic Search Premier, Aerospace Database, Chemical Abstracts Core, Communication Abstracts, Compendex, INSPEC, Metadex, Civil Engineering Abstracts

Abstract

Poly(glycolic acid) (PGA) is an essential biopolymer due to its thermal and mechanical properties and biodegradability which provide utility for medical applications and renewable industry. For biomedical applications, production of PGA with high molecular weight is an essential factor to possess adequate mechanical stability. Primary pathways for PGA synthesis are ring-opening polymerization of glycolide (ROP), direct polycondensation of glycolic acid, and solid-state polycondensation of halogen acetates. For PGA synthesis, different systems have been developed with using varying parameters including catalysis, initiators, solvents, and reaction temperature. This review summarizes the different synthesis pathways and physicochemical properties of PGA. Biomedical applications of PGA are also discussed.