Simultaneous non-enzymatic electrochemical analysis of uric acid and ascorbic acid at an electrodeposited bimetallic CNT fiber microelectrode
Journal of Alloys and Compounds, vol.1068, 2026 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 1068
- Publication Date: 2026
- Doi Number: 10.1016/j.jallcom.2026.188406
- Journal Name: Journal of Alloys and Compounds
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, Chimica, Compendex, INSPEC, Public Affairs Index
- Keywords: Ascorbic acid, CNT fiber, Electrochemical detection, Electrodeposition, Uric acid
- Süleyman Demirel University Affiliated: Yes
Abstract
In this study, a bimetallic nickel-iron oxide modified carbon nanotube fiber (NiFe-O@CNTF) microelectrode was fabricated for the electrochemical sensing of uric acid (UA) and ascorbic acid (AA). NiFe-O nanoparticles were electrodeposited onto novel structured CNTs as twisted fiber (CNTF) via chronoamperometry, forming a catalytically active hybrid interface. Surface morphology and elemental composition were confirmed through scanning electron microscopy (SEM) withenergy-dispersive X-ray spectroscopy (EDX), X-rays diffraction (XRD), Fourier transformation infrared spectroscopy (FTIR) and Raman spectroscopy. The synergistic integration of redox-active metal oxides with the conductive CNTF network as fiber enhanced electron transfer and peak resolution, enabling sensitive detection across physiologically relevant concentration ranges. The sensor exhibited a sensitivity of 51.29 μAmM⁻¹cm⁻² for uric acid, with a detection limit of 80 µM and a quantification limit of 0.25 mM. AA showed a broader linear range (0.13–3.00 mM) with a sensitivity of 5.17 μA mM⁻¹ cm⁻². Staircase chronoamperometry confirmed linear current responses with successive additions of each analyte, exhibiting reasonable linearity (R2= 0.99), highlighting the sensor's efficiency for real-time antioxidant monitoring with precision.