Does sphingosine-1-phosphate have a protective effect on cyclophosphamide- and irradiation-induced ovarian damage in the rat model?

Kaya H., Desdicioglu R., SEZİK M. , ULUKAYA E., Ozkaya O., Yimaztepe A., ...Daha Fazla

FERTILITY AND STERILITY, cilt.89, ss.732-735, 2008 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 89 Konu: 3
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1016/j.fertnstert.2007.03.065
  • Sayfa Sayıları: ss.732-735


The aim of this study was to assess the possible protective effect of sphingosine-1-phosphate (S1P), a polar sphingoid metabolite that seemingly promotes cell survival, on cytotoxin- and irradiation-induced ovarian injury in the rat model. Administration of S I P into ovarian bursa before whole-body irradiation led to decreased percentage of apoptotic cells, mostly in primordial follicles; however, S1P was not effective against apoptosis in rats that were given intraperitoneal cyclophosphamide.