Tissue xanthine oxidase activity and nitric oxide levels after spinal cord ischemia/reperfusion injury in rabbits: Comparison of caffeic acid phenethyl ester (CAPE) and methylprednisolone

Sahin S., Sogut S., Ozyurt H., Uz E., Ilhan A., Akyol O.

NEUROSCIENCE RESEARCH COMMUNICATIONS, vol.31, no.2, pp.111-121, 2002 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 2
  • Publication Date: 2002
  • Doi Number: 10.1002/nrc.10044
  • Journal Name: NEUROSCIENCE RESEARCH COMMUNICATIONS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.111-121
  • Süleyman Demirel University Affiliated: Yes

Abstract

Caffeic acid phenethyl ester exhibits antioxidant properties. This experimental study was designed to determine the effect of CAPE on nitric NO level and XO activity after reperfusion injury of spinal cord. New Zealand white rabbits were undergone aortic occlusion. CAPE, methylprednisolone or saline were injected intraperitoneally before surgical intervention. Animals were subjected to 21 min of crossclamp time. At the end of occlusion time, the clamps were removed and restoration of the blood flow was verified visually. Animals in sham group underwent a surgical procedure similar to the other groups but the aorta was not occluded. Spinal cord specimens were obtained to determine the tissue levels of NO and XO activity.