The objective of this study is to focus on boric acid extraction from the mineral tincal, in order to determine the optimum conditions thanks to the ultrasonic-assisted extraction (UAE) technique (with the response surface methodology (RSM) for the first time), and artificial intelligence based swarm intelligence. Characterization of the tincal were done by using thermo-gravimetric assay (TG-DTA), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR) analyses. In detail, a central composite design (CCD) was used for determining the effects of different solvent/solid ratios, pH, extraction time, and extraction temperature on the yield, which was determined by the conductometric method. The optimum values regarding the best extraction process was calculated by using five different swarm intelligence techniques: Particle swarm optimization (PSO), cuckoo search (CS), genetic algorithms (GA), Differential evolution (DE), and the vortex optimization algorithm (VOA). In the study content, technical details regarding to background and applied experimental processes are given and the findings pointing an approximate 85-92% boron extraction from tincal ore are discussed generally.