4-h mean lactate clearance as a good predictor of adverse outcome in acute cardiogenic pulmonary edema: a pilot study

Vural A., Karapehlivan M., Dolanbay T., Cumaoğlu M. O., Hatip A. Y., Çetinkaya Y., ...Daha Fazla

TURKISH JOURNAL OF BIOCHEMISTRY, cilt.49, sa.3, ss.401-409, 2024 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 49 Sayı: 3
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1515/tjb-2023-0255
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY
  • Derginin Tarandığı İndeksler: Food Science & Technology Abstracts, Scopus, Science Citation Index Expanded (SCI-EXPANDED), Academic Search Premier, Directory of Open Access Journals
  • Sayfa Sayıları: ss.401-409
  • Süleyman Demirel Üniversitesi Adresli: Evet

Özet

Objectives

This pilot study aimed to evaluate the efficacy of the 4-h mean lactate clearance (LACclr) level as a predictive factor for in-hospital outcomes, 30-day mortality, and treatment success in patients with acute cardiogenic pulmonary edema (ACPE), a significant clinical form of acute heart failure (AHF).

Methods

A total of 44 patients diagnosed with acute pulmonary edema were included in the study. The patients were divided into two groups based on lactate levels and negative outcomes, and lactate and LACclr levels and negative outcomes were analyzed using statistical tests such as Fisher’s exact test, Student’s t-test, Mann-Whitney U test, and Receiver operating characteristic (ROC) analysis.

Results

The results indicated a statistically significant difference in the total hospitalization length of stay according to whether the patients had a negative outcome (intubation and in-hospital mortality) (p=0.033). Additionally, the area under the curve (AUC) value for 4-h mean LACclr was 0.795 in all patients, which was statistically significant in predicting 30-day mortality (p=0.033). The optimal cut-off value for the 4-h mean LACclr in predicting 30-day mortality was found to be 5.57 %, with 80 % sensitivity and 66.7 % specificity. The threshold to rule out 30-day mortality for all patients was 18.85 with 100 % sensitivity and 30.2 % specificity (AUC, 0.795 95 % CI [0.546–1.000], p=0.033).

Conclusions

These findings suggest that the 4-h LACclr level, calculated within 4 h of emergency department (ED) presentation, can be used as a predictive indicator for needing intubation, in-hospital mortality, and 30-day mortality and to identify patients at higher risk for adverse outcomes.