Effect of temperature and propylene glycol as a cosolvent on dissolution of clotrimazole Effet de la température et du propylène glycol comme cosolvant sur la dissolution du clotrimazole

Nemati, A.; Rezaei, H.; POTURCU, Kader; Hanaee, J.; Jouyban, A.; Zhao, H.; Rahimpour, E.

doi:10.1016/j.pharma.2022.10.001

Effect of temperature and propylene glycol as a cosolvent on dissolution of clotrimazole Effet de la température et du propylène glycol comme cosolvant sur la dissolution du clotrimazole

Nemati A., Rezaei H., POTURCU K., Hanaee J., Jouyban A., Zhao H., ...More

Annales Pharmaceutiques Francaises, vol.81, no.2, pp.258-266, 2023 (ESCI, Scopus)

Publication Type: Article / Article
Volume: 81 Issue: 2
Publication Date: 2023
Doi Number: 10.1016/j.pharma.2022.10.001
Journal Name: Annales Pharmaceutiques Francaises
Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, PASCAL, BIOSIS, Chemical Abstracts Core, EMBASE, International Pharmaceutical Abstracts, MEDLINE
Page Numbers: pp.258-266
Keywords: Aqueous binary mixtures, Clotrimazole, Cosolvency models, Shake flask method, Solubility
Süleyman Demirel University Affiliated: Yes

Abstract

© 2022 Académie Nationale de PharmacieHerein, the solubility study of clotrimazole was performed in a propylene glycol + water system. The solubility values were fitted to various cosolvency equations. The model accuracies were studied with the computation of the mean relative deviations. The thermodynamic behavior was investigated according to the van't Hoff and Gibbs equations for clotrimazole in the propylene glycol + water system. Furthermore, the density data for clotrimazole were determined in mixtures of propylene glycol + water and fitted to the Jouyban-Acree equation.