Effect of temperature and propylene glycol as a cosolvent on dissolution of clotrimazole Effet de la température et du propylène glycol comme cosolvant sur la dissolution du clotrimazole

Nemati A., Rezaei H., POTURCU K., Hanaee J., Jouyban A., Zhao H., ...More

Annales Pharmaceutiques Francaises, 2022 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2022
  • Doi Number: 10.1016/j.pharma.2022.10.001
  • Journal Name: Annales Pharmaceutiques Francaises
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, PASCAL, BIOSIS, Chemical Abstracts Core, EMBASE, International Pharmaceutical Abstracts, MEDLINE
  • Keywords: Aqueous binary mixtures, Clotrimazole, Cosolvency models, Shake flask method, Solubility
  • Süleyman Demirel University Affiliated: Yes


© 2022 Académie Nationale de PharmacieHerein, the solubility study of clotrimazole was performed in a propylene glycol + water system. The solubility values were fitted to various cosolvency equations. The model accuracies were studied with the computation of the mean relative deviations. The thermodynamic behavior was investigated according to the van't Hoff and Gibbs equations for clotrimazole in the propylene glycol + water system. Furthermore, the density data for clotrimazole were determined in mixtures of propylene glycol + water and fitted to the Jouyban-Acree equation.