Thermodynamic analysis of a renewable-based multi-generation energy production system which produces a number of outputs, such as power, heating, cooling, hot water, hydrogen and oxygen is conducted. This solar-based multi-generation system consists of four main sub-systems: Rankine cycle, organic Rankine cycle, absorption cooling and heating, and hydrogen production and utilization. Exergy destruction ratios and rates, power or heat transfer rates, energy and exergy efficiencies of the system components are carried out. Some parametric studies are performed in order to examine the effects of varying operating conditions (e.g., reference temperature, direct solar radiation and receiver temperature) on the exergy efficiencies of the sub-systems as well as the whole system. The solar-based multigeneration system which has an exergy efficiency of 57.35%, is obtained to be higher than using these sub-systems separately. The evaluation of the exergy efficiency and exergy destruction for the subsystems and the overall system show that the parabolic dish collectors have the highest exergy destruction rate among constituent parts of the solar-based multi-generation system, due to high temperature difference between the working fluid and collector receivers. (C) 2012 Elsevier Ltd. All rights reserved.