Aspirin And Vitamin C Prevent Corn Syrup Induce Renal Damage In Rats


Yeşilot Ş., Aşcı H. , Cankara F. N. , Özgöçmen M. , Saygın M. , Çiçek E.

5th International Congress On Cell Membranes And Oxidative Stress: Focus On Calcium Signaling And Trp Channels, Isparta, Turkey, 9 - 12 September 2014, pp.375

  • Publication Type: Conference Paper / Summary Text
  • City: Isparta
  • Country: Turkey
  • Page Numbers: pp.375

Abstract

Aim Corn syrup (CS) may lead to elevations in uric acid levels and made insulin resistance that cause oxidative stress. So chronic consumption of CS increased possibility of hyperuricemia and chronic kidney disease. The aim of this study was preventive effect of Aspirin (Asp) and Vitamin C (Vit C) on CS induced nephrotoxicity. Material and Methods In our study 250-300g weighing male Sprague Dawley rats are divided into 5 groups each contain 8 rat. CS form (30% of f30) were supplied with drinking water. Groups were; Control, CS, CS+Asp (10 mg/kg/d), CS+ Vit C (200 mg/kg/d) and CS+Asp+Vit C (10 mg/kg/d Asp + 200 mg/kg/d Vit C). Rats in all groups, at the end of 6 weeks following the last application after 24 hours were sacrificed. Kidney tissues were removed to evaluate histopathologically. The histopathologic scores were according to research article of Abdel-Wahhab et al. Results Macro and microvesicular lipoidosis, dilatation and degeneration of the proximal and distal tubule, glomerular degeneration, vascular congestion, hemorrhagic areas, mononuclear cell infiltration and tubular dilatation in medulla was observed in CS group. In CS+Asp and CS+ Vit C groups, there were partial recovery in histopathological findings compared with CS group but it was not significant (p>0.05). Whereas in CS+Asp+Vit C group, there was marked improvement in histopathological findings were observed significantly (p<0.05), compared with CS group. Conclusion Implementation of Asp with vit C, the improvement was detected in renal histopathology. Antioxidants should be recommended in the prevention of kidney damage that occured in oxidative stress of insulin resistance and hyperuricemia for routine use. This issue should be supported by pharmaceutical companies. Keywords Corn syrup, nephrotoxicity, oxidative stress, aspirin and vitamin C