Research Information System
5th International Congress On Cell Membranes And Oxidative Stress: Focus On Calcium Signaling And Trp Channels, Isparta, Turkey, 9 - 12 September 2014, pp.375
Aim
Corn syrup (CS) may lead to elevations in uric
acid levels and made insulin resistance that cause
oxidative stress. So chronic consumption of CS
increased possibility of hyperuricemia and chronic
kidney disease. The aim of this study was preventive
effect of Aspirin (Asp) and Vitamin C (Vit C) on CS
induced nephrotoxicity.
Material and Methods
In our study 250-300g weighing male Sprague
Dawley rats are divided into 5 groups each contain
8 rat. CS form (30% of f30) were supplied with
drinking water. Groups were; Control, CS, CS+Asp
(10 mg/kg/d), CS+ Vit C (200 mg/kg/d) and
CS+Asp+Vit C (10 mg/kg/d Asp + 200 mg/kg/d
Vit C). Rats in all groups, at the end of 6 weeks
following the last application after 24 hours were
sacrificed. Kidney tissues were removed to evaluate
histopathologically. The histopathologic scores were
according to research article of Abdel-Wahhab et
al.
Results
Macro and microvesicular lipoidosis, dilatation
and degeneration of the proximal and distal tubule,
glomerular degeneration, vascular congestion,
hemorrhagic areas, mononuclear cell infiltration
and tubular dilatation in medulla was observed in
CS group. In CS+Asp and CS+ Vit C groups, there
were partial recovery in histopathological findings
compared with CS group but it was not significant
(p>0.05). Whereas in CS+Asp+Vit C group, there
was marked improvement in histopathological
findings were observed significantly (p<0.05),
compared with CS group.
Conclusion
Implementation of Asp with vit C, the
improvement was detected in renal histopathology.
Antioxidants should be recommended in the
prevention of kidney damage that occured
in oxidative stress of insulin resistance and
hyperuricemia for routine use. This issue should be
supported by pharmaceutical companies.
Keywords
Corn syrup, nephrotoxicity, oxidative stress,
aspirin and vitamin C