Objective: Pharmacotherapeutics have been used as a primary agent in migraine treatment. The detection of triggers that exacerbated migraine in recent years and the effectiveness of the surgical interventions applied in this area have been demonstrated. The aim of this study was to investigate the depression, anxiety and quality of life in migraine patients seeking surgical treatment by comparing them with migraine and non-migraine group. Method: A total of 105 participants were included in the study: 35 migraine patients seeking surgical treatment, 35 migraine patients not-seeking surgical treatment, and 35 healthy controls without migraine. Participants filled out forms consisting of Beck Depression Scale, Beck Anxiety Scale, SF-36 Quality of Life Scale and sociodemo-graphic data form. One-way analysis of variance and Post-hoc Bonferroni test were used to assess intergroup depression, anxiety and quality of life scores. Results: Anxiety (F=6,02; p=0,003), and depression (F=10,72; p<0,001) scores were higher in migraine patients seeking surgical treatment group. In the quality of life subscales, bodily pain scores were higher (F=13,09; p<0,001); role-physical (F=14,72; p=0,003) and role-emotional (F=6,11; p=0,003) scores were found to be lower than the other groups. Discussion: Surgical treatment seeking behavior in migraine patients is associated with more severe anxiety and depression and worse quality of life. Psychiatric evaluation of migraine patients seeking surgical treatment may be important in detecting psychiatric disorders at the diagnostic level and in increasing the quality of life of patients.