The importance of neopterin in COVID-19: The prognostic value and relation with the disease severity


Rasmi Y., Heidari N., Kirboga K. K. , Hatamkhani S., Tekin B., Alipour S., ...More

CLINICAL BIOCHEMISTRY, vol.104, pp.1-12, 2022 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 104
  • Publication Date: 2022
  • Doi Number: 10.1016/j.clinbiochem.2022.03.002
  • Title of Journal : CLINICAL BIOCHEMISTRY
  • Page Numbers: pp.1-12
  • Keywords: SARS CoV-2, Neopterin, COVID-19, Prognosis, TUMOR-NECROSIS-FACTOR, HUMAN-IMMUNODEFICIENCY-VIRUS, T-CELL PROLIFERATION, SERUM NEOPTERIN, INTERFERON-GAMMA, TRYPTOPHAN DEGRADATION, OXIDATIVE STRESS, ZINC SUPPLEMENTATION, URINARY NEOPTERIN, HYPOCHLOROUS ACID

Abstract

Coronavirus Disease 2019 [COVID-19], caused by severe acute respiratory syndrome coronavirus 2 [SARS-CoV2], has rapidly evolved into a global health emergency. Neopterin [NPT], produced by macrophages when stimulated with interferon [IFN-]gamma, is an essential cytokine in the antiviral immune response. NPT has been used as a marker for the early assessment of disease severity in different diseases. The leading cause of NPT production is the pro-inflammatory cytokine IFN-. Macrophage activation has also been revealed to be linked with disease severity in SARS-CoV-2 patients. We demonstrate the importance of NPT in the pathogenesis of SARS-CoV-2 and suggest that targeting NPT in SARS-CoV-2 infection may be critical in the early prediction of disease progression and provision of timely management of infected individuals.