Transient focal cerebral ischemia-induced neurogenesis in the dentate gyrus of the adult mouse


Tureyen K., Vemuganti R., Sailor K., Bowen K., Dempsey R.

JOURNAL OF NEUROSURGERY, vol.101, no.5, pp.799-805, 2004 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 101 Issue: 5
  • Publication Date: 2004
  • Doi Number: 10.3171/jns.2004.101.5.0799
  • Title of Journal : JOURNAL OF NEUROSURGERY
  • Page Numbers: pp.799-805

Abstract

Object. Throughout the life of a mammal, new neurons are produced each day from resident progenitor cells located in the hippocampal dentate gyrus (DG). The availability of transgenic and knockout mice enables the evaluation of specific molecular mediators of this phenomenon. To facilitate such studies the authors characterized the proliferation, survival, and maturation of progenitor cells in the DG of adult mice following transient focal cerebral ischemia.