Effect of thymoquinone on ameliorating valproic acid-induced damage in pancreatic tissue of rats

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AZIRAK S., BİLGİÇ S., TAŞTEMİR KORKMAZ D., SEVİMLİ M. , ÖZER M. K.

CUKUROVA MEDICAL JOURNAL, vol.47, no.1, pp.350-359, 2022 (Journal Indexed in ESCI)

• Publication Type: Article / Article
• Volume: 47 Issue: 1
• Publication Date: 2022
• Doi Number: 10.17826/cumj.1020753
• Title of Journal : CUKUROVA MEDICAL JOURNAL
• Page Numbers: pp.350-359
• Keywords: thymoquinone, valproic acid, apoptosis, toxicity, HDAC1/2, HISTONE DEACETYLASE INHIBITORS, OXIDATIVE STRESS, CANCER, ANTITUMOR, ANGIOGENESIS, APOPTOSIS, MODEL

Abstract

Purpose: The aim of this study was to evaluate the potential effect of thymoquinone (TQ) in preventing or treating valproic acid (VPA)-induced pancreatic injury, gene expressions and histopathological changes in pancreatic tissue of rats..