An evaluation of normal saline and taurolidine on intra-abdominal adhesion formation and peritoneal fibrinolysis

TARHAN Ö. R., BARUT İ., SEZİK M.

JOURNAL OF SURGICAL RESEARCH, vol.144, no.1, pp.151-157, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 144 Issue: 1
  • Publication Date: 2008
  • Doi Number: 10.1016/j.jss.2007.09.006
  • Journal Name: JOURNAL OF SURGICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.151-157
  • Keywords: peritoneal adhesions, peritoneal fibrinolysis, normal saline, taurolidine, tPA, tPA activity, PAI-1, tPA/PAI-1 complex, hydroxyproline, INTRAPERITONEAL TUMOR-GROWTH, POSTOPERATIVE ADHESIONS, PLASMINOGEN-ACTIVATOR, CLINICAL-SIGNIFICANCE, SURGICAL TRAUMA, PELVIC-SURGERY, RAT MODEL, PREVENTION, ETIOLOGY, TISSUE
  • Süleyman Demirel University Affiliated: Yes

Abstract

Background. Intraoperative lavage with normal saline or taurolidine solutions is commonly used in abdominal surgery. For this purpose, normal saline and taurolidine, which may modify the intrinsic fibrinolytic activity of the peritoneum by breaking the peritoneal adhesions, are frequently used. We aimed to evaluate how normal saline and taurolidine affect peritoneal fibrinolysis and adhesion formation.