Gemcitabine hydrochloride microspheres used for intravesical treatment of superficial bladder cancer: a comprehensive in vitro/ex vivo/in vivo evaluation

KARAVANA S. Y. , Senyigit Z. A. , ÇALIŞKAN Ç., SEVİN G., Ozdemir D. I. , Erzurumlu Y., ...More

DRUG DESIGN DEVELOPMENT AND THERAPY, vol.12, pp.1959-1975, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 12
  • Publication Date: 2018
  • Doi Number: 10.2147/dddt.s164704
  • Journal Name: DRUG DESIGN DEVELOPMENT AND THERAPY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1959-1975
  • Süleyman Demirel University Affiliated: No

Abstract

Introduction: Bladder cancer is responsible for more than 130,000 deaths annually worldwide. Intravesical delivery of chemotherapeutic agents provides effective drug localization to the target area to reduce toxicity and increase efficacy. This study aimed to develop ail intravesical delivery system of gemcitabine HC1 (Gem-HCl) to provide a sustained-release profile, to prolong residence time, and to enhance its efficiency in the treatment of bladder cancer.