Gemcitabine hydrochloride microspheres used for intravesical treatment of superficial bladder cancer: a comprehensive in vitro/ex vivo/in vivo evaluation

KARAVANA S. Y. , Senyigit Z. A. , ÇALIŞKAN Ç., SEVİN G., Ozdemir D. I. , Erzurumlu Y. , ...Daha Fazla

DRUG DESIGN DEVELOPMENT AND THERAPY, cilt.12, ss.1959-1975, 2018 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 12
  • Basım Tarihi: 2018
  • Doi Numarası: 10.2147/dddt.s164704
  • Dergi Adı: DRUG DESIGN DEVELOPMENT AND THERAPY
  • Sayfa Sayıları: ss.1959-1975

Özet

Introduction: Bladder cancer is responsible for more than 130,000 deaths annually worldwide. Intravesical delivery of chemotherapeutic agents provides effective drug localization to the target area to reduce toxicity and increase efficacy. This study aimed to develop ail intravesical delivery system of gemcitabine HC1 (Gem-HCl) to provide a sustained-release profile, to prolong residence time, and to enhance its efficiency in the treatment of bladder cancer.