Investigation of pulmonary involvement in inflammatory bowel disease in an experimental model of colitis

AYDIN B., SONGUR Y., SONGUR N., AKSU O., Senol A., ÇİRİŞ İ. M., ...More

KOREAN JOURNAL OF INTERNAL MEDICINE, vol.31, no.5, pp.853-859, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 5
  • Publication Date: 2016
  • Doi Number: 10.3904/kjim.2014.238
  • Journal Name: KOREAN JOURNAL OF INTERNAL MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.853-859
  • Süleyman Demirel University Affiliated: Yes

Abstract

Background/Aims: Inflammatory bowel disease (IBD) may also involve various extra-intestinal organs. Clinical studies have found asymptomatic/symptomatic pulmonary involvement in 1% to 6% of patients with IBD. The present study histopathologically investigated pulmonary involvement in an experimental model of colitis in order to demonstrate pulmonary tissue involvement in IBD and to expose potential etiological factors. It also explored the relation between inflammation and tissue concentrations of vascular endothelial growth factor (VEGF) and tumor necrosis factor alpha (TNF-alpha).