Anti-inflammatory action of fluvoxamine in an endotoxin-induced uveitis rat model: Histopathological evidence
Molecular Vision, cilt.32, ss.255-263, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 32
- Basım Tarihi: 2026
- Dergi Adı: Molecular Vision
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, MEDLINE, Directory of Open Access Journals, Health Research Premium Collection (ProQuest)
- Sayfa Sayıları: ss.255-263
- Süleyman Demirel Üniversitesi Adresli: Evet
Özet
Purpose: To investigate the potential protective effects of fluvoxamine (FVX), a selective serotonin reuptake inhibitor with known anti-inflammatory properties, on corneal, limbal, and retinal tissues in a rat model of endotoxin-induced uveitis (EIU), clinical and histopathologic evaluations were performed. Methods: Twenty-eight female Wistar Albino rats were divided into four groups: controls, EIU, EIU + FVX, and FVX (n = 7 per group). EIU was induced by a single intraperitoneal injection of lipopolysaccharide (LPS). FVX or normal saline (NS) was administered 30 min before LPS or NS injection. Clinical ocular inflammation was assessed using slit-lamp biomicroscopy 6 h postinjection. Following euthanasia, enucleated eyes were processed for histopathologic analysis of corneal, limbal, and retinal tissues. Results: Total corneal and epithelial thickness were measured, while limbal and retinal lesions were semiquantitatively graded. The EIU group exhibited significantly increased clinical ocular inflammation scores compared to the control, EIU + FVX, and FVX groups (p < 0.0001 for all). At the microscopical analysis, the EIU group showed significant corneal epithelial thickening, cellular changes, edema, hemorrhage, and increased total corneal thickness compared to the control group (p < 0.001). In addition, histopathologic analysis revealed retinal hyperemia and edema in the EIU group but not in the EIU + FVX, FVX, or control groups. Histopathologic scores confirmed significant retinal changes in the EIU group compared to the others (p < 0.001). Conclusions: FVX significantly reduced clinical signs of ocular inflammation and mitigated histopathologic damage in the cornea, limbus, and retina.