The role of endothelial glycocalyx in health and disease
CLINICAL KIDNEY JOURNAL, cilt.12, sa.5, ss.611-619, 2019 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 12 Sayı: 5
- Basım Tarihi: 2019
- Doi Numarası: 10.1093/ckj/sfz042
- Dergi Adı: CLINICAL KIDNEY JOURNAL
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.611-619
- Süleyman Demirel Üniversitesi Adresli: Evet
Özet
The endothelium is the largest organ in the body and recent studies have shown that the endothelial glycocalyx (eGCX) plays a major role in health and disease states. The integrity of eGCX is vital for homoeostasis and disruption of its structure and function plays a major role in several pathologic conditions. An increased understanding of the numerous pathophysiological roles of eGCX may lead to the development of potential surrogate markers for endothelial injury or novel therapeutic targets. This review provides a state-of-the-art update on the structure and function of the eGCX, emphasizing the current understanding of interorgan crosstalk between the eGCX and other organs that might also contribute to the pathogenesis of kidney diseases.