Alpha lipoic acid attenuates hypoxia-induced apoptosis, inflammation and mitochondrial oxidative stress via inhibition of TRPA1 channel in human glioblastoma cell line

DEVECİ, HACİ; Akyuva, Yener; NUR, GÖKHAN; NAZIROĞLU, Mustafa

doi:10.1016/j.biopha.2018.12.077

Alpha lipoic acid attenuates hypoxia-induced apoptosis, inflammation and mitochondrial oxidative stress via inhibition of TRPA1 channel in human glioblastoma cell line

DEVECİ H. A., Akyuva Y., NUR G., NAZIROĞLU M.

BIOMEDICINE & PHARMACOTHERAPY, cilt.111, ss.292-304, 2019 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 111
Basım Tarihi: 2019
Doi Numarası: 10.1016/j.biopha.2018.12.077
Dergi Adı: BIOMEDICINE & PHARMACOTHERAPY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.292-304
Süleyman Demirel Üniversitesi Adresli: Evet

Özet

Apoptosis, overload Ca2+ entry and oxidative stress are induced in neurons by hypoxia. Drug-resistant cancer cells are killed by hypoxic conditions. a-Lipoic acid (ALA) has antioxidant and pro-oxidant functions. The TRPA1 channel is activated by oxidative stress and pro-oxidant ALA may have a regulator role in the TRPA1 activity in the human glioblastoma (DBTRG) cells. The aim of this study was to evaluate if a combination therapy of ALA with a hypoxia can alter the effect of this hypoxia through TRPA1 activation in the DBTRG cells.