Alpha lipoic acid attenuates hypoxia-induced apoptosis, inflammation and mitochondrial oxidative stress via inhibition of TRPA1 channel in human glioblastoma cell line


DEVECİ H. A. , Akyuva Y., NUR G., NAZIROĞLU M.

BIOMEDICINE & PHARMACOTHERAPY, cilt.111, ss.292-304, 2019 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 111
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.biopha.2018.12.077
  • Dergi Adı: BIOMEDICINE & PHARMACOTHERAPY
  • Sayfa Sayıları: ss.292-304

Özet

Apoptosis, overload Ca2+ entry and oxidative stress are induced in neurons by hypoxia. Drug-resistant cancer cells are killed by hypoxic conditions. a-Lipoic acid (ALA) has antioxidant and pro-oxidant functions. The TRPA1 channel is activated by oxidative stress and pro-oxidant ALA may have a regulator role in the TRPA1 activity in the human glioblastoma (DBTRG) cells. The aim of this study was to evaluate if a combination therapy of ALA with a hypoxia can alter the effect of this hypoxia through TRPA1 activation in the DBTRG cells.