Background and Aim: The purpose of this in vivo study was to investigate the effect of translucent adhesive resin cement on the final color of ceramic laminate veneer restoration before and after polymerization in intraoral conditions. Materials and Methods: This study was conducted in 92 ceramic laminate veneer restorations of 27 patients. The ceramic laminate veneer restorations in standard thickness lithium disilicate ceramic structure (IPS e.max Press HT, Ivoclar Vivadent) were cemented to the tooth with translucent light-polymerized resin cement (Choice 2 Starter Kit, Bisco). Results: It was observed a clinically noticeable color change between delta E values before and after polymerization (delta E > 3.3). There was a statistically significant difference in b* values, delta L value, and delta b value. Conclusion: Within the limitations of this in vivo study, the results suggest that light polymerization of the translucent resin cement (Choice 2, Bisco) used is an important factor for the final color of the restoration and should be considered during shade selection and fabrication.