Systemic sclerosis (SS) is a systemic autoimmune disease progressing with fibrosis of the skin and internal organs, the cause of which cannot be precisely explained. The disease is known to be associated with environmental factors. In particular, exposure to silica powders is believed to have a part in the pathogenesis of the disease by the triggering of a number of immune reactions. Silicosis and SS association is defined as Erasmus Syndrome (ES). Here, we report on a 30-year-old patient working in denim sandblasting who developed SS while being followed for 6 years due to silicosis.