Analysis of Serum VEGF, IGF-1, and HIF-1α Levels in ADHD


Journal of Attention Disorders, 2023 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2023
  • Doi Number: 10.1177/10870547231197211
  • Journal Name: Journal of Attention Disorders
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus, CINAHL, MEDLINE, Psycinfo
  • Keywords: ADHD, growth factors, HIF-1α, IGF-1, VEGF
  • Süleyman Demirel University Affiliated: Yes


Objective: In recent years, it has been emphasized that various growth factors that affect neurogenesis may lead to ADHD. In this study, we aimed to investigate the role of VEGF, IGF-1, and HIF-1α growth factors in the etiopathogenesis of ADHD. Method: Levels of VEGF, IGF-1, and HIF-1α were compared between 40 ADHD children and 40 healthy children, aged 7 to 13 years. Result: VEGF, IGF-1, and HIF-1α levels did not significantly differ between the groups. There was a negative correlation between serum VEGF levels and the parent-rated T-DSM-IV-S (AD) subscale. There was a positive correlation between serum IGF-1 levels and the parent-rated T-DSM-IV-S (AD) subscale, and SDQ (ES) subscale. Conclusion: Given our limitations and the fact that some of our findings differ from those of other studies, it is evident that this area requires additional research with larger samples.