The effect of energy restriction on development and progression of chronic kidney disease: review of the current evidence.
The British journal of nutrition, cilt.125, ss.1201-1214, 2021 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 125
- Basım Tarihi: 2021
- Doi Numarası: 10.1017/s000711452000358x
- Dergi Adı: The British journal of nutrition
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, Agricultural & Environmental Science Database, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Chemical Abstracts Core, CINAHL, EMBASE, Environment Index, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
- Sayfa Sayıları: ss.1201-1214
- Anahtar Kelimeler: Energy restriction, Chronic kidney disease, Energy restriction mimetics, Autophagy, Mammalian target of rapamycin pathway, TERM CALORIE RESTRICTION, ISCHEMIA-REPERFUSION INJURY, DIETARY RESTRICTION, OXIDATIVE STRESS, RENAL-DISEASE, CARBOHYDRATE RESTRICTION, DIABETIC-NEPHROPATHY, WEIGHT-LOSS, PROTEIN, EXPRESSION
- Süleyman Demirel Üniversitesi Adresli: Evet
Özet
Energy restriction (ER) has anti-ageing effects and probably protects from a range of chronic diseases including cancer, diabetes and chronic kidney disease (CKD). Specifically, ER has a positive impact on experimental kidney ageing, CKD (diabetic nephropathy, polycystic kidney disease) and acute kidney injury (nephrotoxic, ischaemia-reperfusion injury) through such mechanisms as increased autophagy, mitochondrial biogenesis and DNA repair, and decreased inflammation and oxidative stress. Key molecules contributing to ER-mediated kidney protection include adenosine monophosphate-activated protein kinase, sirtuin-1 and PPAR-gamma coactivator 1 alpha. However, CKD is a complex condition, and ER may potentially worsen CKD complications such as protein-energy wasting, bone-mineral disorders and impaired wound healing. ER mimetics are drugs, such as metformin and Na-glucose co-transporter-2 which mimic the action of ER. This review aims to provide comprehensive data regarding the effect of ER on CKD progression and outcomes.