Skin friction and some performance characteristics of single jersey fabrics produced from cotton (combed, carded and rotor) and regenerated cellulosic fiber (viscose, bamboo, modal, micromodal, Tencel (R), Tencel LF (R) and some blends) yarns were investigated by surface friction, bursting strength, abrasion and pilling resistance tests. Daily or functional socks were the intended end use of the selected materials. According to the results, cotton, 48/52% cotton/modal and Tencel (R) fabrics have higher bursting strength. Pilling and abrasion resistances are the highest for also 48/52% cotton/modal fabric. For skin friction which is crucial for socks within shoes, rotor viscose, 48/52% cotton/modal and micromodal have smoother surfaces than modal and Tencel (R) for both kinetic and static friction coefficients. It means that these materials create less injuries on sweaty skin during an activity. It is thought that, results obtained for cotton and different regenerated cellulosic fabrics are valid also for all next-to-skin garments.