Serum zonulin levels in type 2 diabetes patients with diabetic kidney disease.

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Sirin F. B. , Korkmaz H., Eroglu I., Afsar B., Kumbul Doguc D.

Endokrynologia Polska, vol.72, pp.545-549, 2021 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 72
  • Publication Date: 2021
  • Doi Number: 10.5603/ep.a2021.0056
  • Journal Name: Endokrynologia Polska
  • Journal Indexes: Science Citation Index Expanded, Scopus, CINAHL, EMBASE, MEDLINE, Directory of Open Access Journals
  • Page Numbers: pp.545-549
  • Keywords: type 2 diabetes mellitus, diabetic kidney disease, intestinal permeability, zonulin, inflammation, INFLAMMATION, PERMEABILITY, HYPERTENSION, FAILURE


Introduction: Recent data have shown that diabetic kidney disease (DKD) is associated with abnormal gut microbiota composition. Zonulin is a physiological tight junction modulator and an intestinal permeability marker. In this study we aimed to investigate serum levels of zonulin and interleukin 6 (IL-6) in patients with type 2 diabetes mellitus (T2DM) and different levels of albuminuria.