Splenectomy attenuates intestinal ischemia-reperfusion - Induced acute lung injury


Savas M. Ç. , OZGUNER M., OZGUNER I., DELIBAS N.

JOURNAL OF PEDIATRIC SURGERY, vol.38, no.10, pp.1465-1470, 2003 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 10
  • Publication Date: 2003
  • Doi Number: 10.1016/s0022-3468(03)00497-4
  • Title of Journal : JOURNAL OF PEDIATRIC SURGERY
  • Page Numbers: pp.1465-1470

Abstract

Background/Purpose: Intestinal ischemia-reperfusion (IIR) induced acute lung injury (ALI) has been documented. Kupffer cell blockage with gadolinium chloride (GdCl3) has been shown to attenuate IIR-induced ALI. However, the effects of splenic monocytes/macrophages on IIR-induced ALI has not been studied previously. In the current study, the authors aimed to investigate the role of splenectomy in IIR-incluced ALI.