Clinical use of copeptin in migraine patients admitted to the emergency department

Creative Commons License

Yılmaz D., Armağan H. H., Karaman K., Şirin F. B., Bozkurt M., Karaibrahimoğlu A., ...More

AMERICAN JOURNAL OF EMERGENCY MEDICINE, vol.38, no.9, pp.1910-1914, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 9
  • Publication Date: 2020
  • Doi Number: 10.1016/j.ajem.2020.05.009
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, Biotechnology Research Abstracts, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.1910-1914
  • Keywords: Copeptin, Emergency, Headache, Migraine, VASOPRESSIN, HEADACHE
  • Süleyman Demirel University Affiliated: Yes


Purpose: The purpose of this study was to investigate the clinical use of copeptin to evaluate migraine attacks in
the Emergency Department. An additional aim was to detect changes in serum copeptin levels in migraine patients
during attack and attack-free periods.
Methods: This prospective case–control study included 52 migraine patients and 51 healthy individualswith similar
demographic characteristics. Blood sampleswere collected from migraine patients both in attack and attackfree
Results: The mean copeptin levels in the patients group in the attack and attack-free periods were 689.28 and
576.68 pg/ml, respectively, whereas they were 608.68 pg/ml in the control group. There was a significant difference
in the mean copeptin level in the attack period and attack-free periods (p = 0.026). The sensitivity and
specificity of copeptin in detecting headache episodes in migraine patients were 58.8% and 60.7%, respectively,
at a cut-off value of 388.67 pg/ml.
Conclusion: This is the first study to investigate the diagnostic efficacy of serum copeptin levels in migraine patients.
Although the diagnostic efficacy of serum copeptin levels for migraines was unsatisfactory, it could be
helpful at management of migraine patients in ED.