In the study, spatial distribution maps of rainfall in the Mediterranean Region have been prepared with Geographic Information Systems (GIS). Inverse Distance Weighted (IDW), Kriging and Spline interpolation methods have been used. The accuracy analysis of maps has been made regarding the determination coefficient (R-2) and the root mean square error values. Examining results of the analysis, it has been determined that IDW interpolation method usually provides appropriate results. Moreover, Kriging interpolation method gives higher R-2 values than IDW method in various stations. It has been found out that IDW interpolation method is applicable in spatial distribution of rainfall in the Mediterranean Region.