Bone Mineral Density and the Relationship between Lipid Profile and Bone Mineral Density in the Rats Administered Juniperus Communis Linn.


USKUN E. , AKDOGAN M., YILDIZ M. , SONMEZ Y.

JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN, cilt.34, ss.802-806, 2012 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 34 Konu: 4
  • Basım Tarihi: 2012
  • Dergi Adı: JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN
  • Sayfa Sayıları: ss.802-806

Özet

The aim of the study is to investigate the relationship of Juniperus Communis Lynn. with the bone mineral density in the rats fed with a high cholesterol (1%) diet. Thirty five Wistar albino rats weighed approximately 250-300 were used in this study. The rats are divided in five groups of seven each. Groups I and II were administered 0.5 ml of 0.5% Sodium Carboxy Methyl Cellulose (SCMC), while Groups II, IV and V administered 0.5 ml of juniperus communis linn dissolved in 25, 50, 100 mg/kg. Group I and Group II were fed with normal pellets while the other four groups were fed with pellets containing 1% cholesterol. Levels of lipid profile and High Density Lipoprotein Cholesterol (HDL-C) were defined in all the groups. Furthermore, bone mineral density (B M D) of the animals were obtained with DEXA scanner. BMD values of the rats did not show a different among the groups. Significant negative correlations were determined between BMD measurements and LDL-C levels in all groups connected with dose of Juniperus Communis oil. However, this relationship was not linear.