Research Information System
in: SCIENTIFIC RESEARCHES-2, Prof. Dr. Sevi ÖZ, Editor, İksad Yayınevi, Ankara, pp.35-51, 2022
Cardiovascular (heart and vascular) diseases are today's and
developing leading causes of mortality (death) and morbidity (incapacity) in
countries for a number of reasons. In addition, due to its direct or indirect
costs, health plays a major role in spending. In many European countries in
recent years, cardiovascular disease mortality rates are significantly lower. is
doing. Although it has decreased, it still remains the most important cause of
premature death in Europe. More than 80% of cardiovascular disease deaths
occur in developing countries. It is estimated to occur (Narla et al. 2009, Uyar
2009, Perk et al. 2012). In the decreasing trend of cardiovascular disease in
developed countries, the behavior of society's conservation programs aimed at
change has had an impact. Studies have shown that an unhealthy lifestyle and
social environment are the basis of cardiovascular diseases. (Arıkan et al.
2009).
Cholesterol is divided into two types: Our health depends on the
presence of benign cholesterol (HDL), which is important in the body and
should have high levels. HDL helps excess cholesterol in our bodies reach the
liver, where it is processed and excreted through the digestive system. HDL is
known as "good cholesterol" because it slows blood circulation and eliminates
cholesterol from the body that causes vascular blockage. On the other hand,
malignant cholesterol (LDL) is a protein that is generated in the liver and
carried through the bloodstream. LDL has various positive qualities in
addition to being well-known. When LDL (Güven A., 2005), which transports
antioxidants and amino acids to other cells, is detected in excess in the human
body, it has a deleterious impact on the body. As a result, diagnosis and
therapy are critical. Drugs like ezetimibe and simvastatin are used to treat the
condition. As a result, atorvastatin and ezetimibe concentrations must be
determined. UV spectroscopy data was used to make chemometric
measurements of cholesterol medications in this research.