SIMULTANEOUS DETERMINATION CHOLESTEROLREDUCING COMBINATION USING PRINCIPAL COMPONENTS REGRESSION METHOD


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Ertokuş G. , Bakan C.

in: SCIENTIFIC RESEARCHES-2, Prof. Dr. Sevi ÖZ, Editor, İksad Yayınevi, Ankara, pp.35-51, 2022

  • Publication Type: Book Chapter / Chapter Research Book
  • Publication Date: 2022
  • Publisher: İksad Yayınevi
  • City: Ankara
  • Page Numbers: pp.35-51
  • Editors: Prof. Dr. Sevi ÖZ, Editor

Abstract

Cardiovascular (heart and vascular) diseases are today's and developing leading causes of mortality (death) and morbidity (incapacity) in countries for a number of reasons. In addition, due to its direct or indirect costs, health plays a major role in spending. In many European countries in recent years, cardiovascular disease mortality rates are significantly lower. is doing. Although it has decreased, it still remains the most important cause of premature death in Europe. More than 80% of cardiovascular disease deaths occur in developing countries. It is estimated to occur (Narla et al. 2009, Uyar 2009, Perk et al. 2012). In the decreasing trend of cardiovascular disease in developed countries, the behavior of society's conservation programs aimed at change has had an impact. Studies have shown that an unhealthy lifestyle and social environment are the basis of cardiovascular diseases. (Arıkan et al. 2009). Cholesterol is divided into two types: Our health depends on the presence of benign cholesterol (HDL), which is important in the body and should have high levels. HDL helps excess cholesterol in our bodies reach the liver, where it is processed and excreted through the digestive system. HDL is known as "good cholesterol" because it slows blood circulation and eliminates cholesterol from the body that causes vascular blockage. On the other hand, malignant cholesterol (LDL) is a protein that is generated in the liver and carried through the bloodstream. LDL has various positive qualities in addition to being well-known. When LDL (Güven A., 2005), which transports antioxidants and amino acids to other cells, is detected in excess in the human body, it has a deleterious impact on the body. As a result, diagnosis and therapy are critical. Drugs like ezetimibe and simvastatin are used to treat the condition. As a result, atorvastatin and ezetimibe concentrations must be determined. UV spectroscopy data was used to make chemometric measurements of cholesterol medications in this research.