Spectrophotometric Determination of Acidity Constants of Some Macrolides in Acetonitrile-Water Binary Mixtures
ACTA CHIMICA SLOVENICA, cilt.57, sa.4, ss.980-987, 2010 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 57 Sayı: 4
- Basım Tarihi: 2010
- Dergi Adı: ACTA CHIMICA SLOVENICA
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.980-987
- Süleyman Demirel Üniversitesi Adresli: Evet
Özet
The acidity constants of eight macrolides (erythromycin, roxithromycin. oleandomycin, azithromycin, josamycin, tylosin tartrate, tilmicosin and spiramycin) have been determined in acetonitrile-water binary mixtures (30%, 40% and 50% (v/v)) by spectrophotometric method. The pK(a)'s available in literature determined by various methods are compiled in comparison with the value of this work. These results are expected to essentially facilitate the research on occurrence, fate and effects, analysis method development, and control of antibiotics in various treatment occurrences.