The Effects of Adjuvant Immunoglobulin M-enriched Immunoglobulin Therapy on Mortality Rate and Renal Function in Sepsis-induced Multiple Organ Dysfunction Syndrome: Retrospective Analysis of Intensive Care Unit Patients

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Yavuz L., Aynali G., Aynali A., Alaca A., Kutuk S., Ceylan B. G.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, vol.40, no.3, pp.1166-1174, 2012 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 3
  • Publication Date: 2012
  • Doi Number: 10.1177/147323001204000337
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.1166-1174


OBJECTIVE: To determine the effect of immunoglobulin (Ig)M-enriched Ig therapy on mortality rate and renal function in sepsis-induced multiple organ dysfunction syndrome (MODS), using the Acute Physiology and Chronic Health Evaluation II (APACHE II) score. METHODS: Retrospective study of patients with sepsis-induced MODS treated with standard antibiotic plus supportive therapy (control group) or IgM-enriched Ig therapy adjuvant to control group therapy (IVIg group). Total length of stay in the intensive care unit (ICU), overall mortality rate and 28-day case fatality rate (CFR), as well as APACHE II scores and renal function parameters at day 1 and day 4 of therapy, were recorded. RESULTS: A total of 118 patients were included (control group, n = 62; IVIg group, n = 56). In both groups, day 4 APACHE II scores decreased significantly compared with day 1 scores; the effect of treatment on renal function was minimal. Length of ICU stay, overall mortality rate and 28-day CFR were significantly lower in the IVIg group compared with the control group. CONCLUSIONS: Adding IgM-enriched Ig therapy to standard therapy for MODS improved general clinical conditions and significantly reduced APACHE II scores, overall mortality rate and 28-day CFR, although effects on renal function were minimal.