Evaluation of monocyte to HDL cholesterol ratio and other inflammatory markers in patients with psoriasis.

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Sirin M., Korkmaz S., Erturan I., Filiz B., Aridogan B., Sesli Cetin E., ...Daha Fazla

Anais brasileiros de dermatologia, cilt.95, ss.575-582, 2020 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 95
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.abd.2020.02.008
  • Dergi Adı: Anais brasileiros de dermatologia
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
  • Sayfa Sayıları: ss.575-582
  • Anahtar Kelimeler: Biological markers, Cholesterol, HDL, C-Reactive protein, Inflammation, Monocytes, Psoriasis, Serum amyloid A protein, MEAN PLATELET VOLUME, C-REACTIVE PROTEIN, LYMPHOCYTE RATIO, SYSTEMIC INFLAMMATION, DISEASE SEVERITY, NEUTROPHIL, VULGARIS, BIOMARKERS, ACTIVATION, EVENTS
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Süleyman Demirel Üniversitesi Adresli: Evet

Özet

Background: Psoriasis is a chronic systemic inflammatory disease frequently associated with

serious comorbidities.

Objectives: To investigate the systemic inflammatory burden in psoriasis and to assess the

correlation between traditional and novel inflammatory markers and the severity of the disease.

Methods: This cross-sectional study was conducted on 60 patients with psoriasis vulgaris and

50 healthy volunteers. Data including demographics, Psoriasis Area and Severity Index scores,

and laboratory results were analyzed and compared.

Results: Compared with the control group, the psoriatic patients had significantly higher high

sensitive C-reactive protein, serum amyloid A, erythrocyte sedimentation rate, leukocyte,

neutrophil, neutrophil-to-lymphocyte ratio, monocyte to high density lipoprotein (HDL) cholesterol

ratio, and aspartate aminotransferase levels, and significantly lower HDL cholesterol

levels (p < 0.05). No significant difference was found in procalcitonin, lymphocyte, monocyte,

hemoglobin, red blood cell distribution width, platelet, mean platelet volume, platelet distribution

width, lymphocyte-to-monocyte ratio, anti-cyclic citrullinated peptide, glucose, alanine

aminotransaminase, blood urea nitrogen, creatinine, triglyceride, total cholesterol, and LDL

cholesterol levels between the two groups (p > 0.05). The Psoriasis Area and Severity Index

score was positively correlated with high-sensitivity C-reactive protein, serum amyloid A, and

monocyte to HDL cholesterol ratio, and negatively correlated with lymphocyte-to-monocyte

ratio (p < 0.05).

Study limitations: This was a single-center study with relatively limited numbers of patients

and controls.