Background: Psoriasis is a chronic systemic inflammatory disease frequently associated with
Objectives: To investigate the systemic inflammatory burden in psoriasis and to assess the
correlation between traditional and novel inflammatory markers and the severity of the disease.
Methods: This cross-sectional study was conducted on 60 patients with psoriasis vulgaris and
50 healthy volunteers. Data including demographics, Psoriasis Area and Severity Index scores,
and laboratory results were analyzed and compared.
Results: Compared with the control group, the psoriatic patients had significantly higher high
sensitive C-reactive protein, serum amyloid A, erythrocyte sedimentation rate, leukocyte,
neutrophil, neutrophil-to-lymphocyte ratio, monocyte to high density lipoprotein (HDL) cholesterol
ratio, and aspartate aminotransferase levels, and significantly lower HDL cholesterol
levels (p < 0.05). No significant difference was found in procalcitonin, lymphocyte, monocyte,
hemoglobin, red blood cell distribution width, platelet, mean platelet volume, platelet distribution
width, lymphocyte-to-monocyte ratio, anti-cyclic citrullinated peptide, glucose, alanine
aminotransaminase, blood urea nitrogen, creatinine, triglyceride, total cholesterol, and LDL
cholesterol levels between the two groups (p > 0.05). The Psoriasis Area and Severity Index
score was positively correlated with high-sensitivity C-reactive protein, serum amyloid A, and
monocyte to HDL cholesterol ratio, and negatively correlated with lymphocyte-to-monocyte
ratio (p < 0.05).
Study limitations: This was a single-center study with relatively limited numbers of patients