The effect of sodium valproate on chronic daily headache and its subgroups

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YÜREKLİ V. A. , Akhan G., KUTLUHAN S. , Uzar E., KOYUNCUOĞLU H. R. , Gultekin F.

JOURNAL OF HEADACHE AND PAIN, vol.9, no.1, pp.37-41, 2008 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 1
  • Publication Date: 2008
  • Doi Number: 10.1007/s10194-008-0002-5
  • Page Numbers: pp.37-41


The objective of the study was to assess the efficacy and tolerability of sodium valproate (VPA) on chronic daily headache (CDH) in a prospective, double-blind, randomized, placebo-controlled trial. Seventy patients were included in the study. Twenty-nine had chronic migraine ( CM) and 41 had chronic tension-type headache ( CTTH). VPA and placebo were applied for 3 months to 40 and 30 patients, respectively. Visual analog scale ( VAS) and pain frequency (PF) were used for evaluation. VPA decreased the maximum pain VAS levels (MaxVAS) and PF at the end of the study ( P = 0.028 and P = 0.000, respectively), but did not change general pain VAS (GnVAS) levels ( P = 0.198). In CM patients, the decreases in MaxVAS, GnVAS and PF parameters were more in VPA treated patients ( P = 0.006, P = 0.03, and P = 0.000, respectively). VPA treatment caused more reduction in PF than placebo in the CTTH subgroup ( P = 0.000). VPA is effective in the prophylactic treatment of CDH by reducing MaxVAS levels and PF. It was more effective in CM than in CTTH.