Fingolimod against endotoxin-induced fetal brain injury in a rat model

YAVUZ A., SEZİK M. , Ozmen O., AŞCI H.

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, vol.43, no.11, pp.1708-1713, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 43 Issue: 11
  • Publication Date: 2017
  • Doi Number: 10.1111/jog.13444
  • Title of Journal : JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
  • Page Numbers: pp.1708-1713
  • Keywords: endotoxin, fetal brain injury, fingolimod, neuroprotection, preterm birth, PRETERM, PREGNANCY, INFECTION, PREVENTS, PROTECTS, FTY720, BIRTH

Abstract

AimFingolimod is a sphingosine-1-phosphate receptor modulator used for multiple sclerosis treatment and acts on cellular processes such as apoptosis, endothelial permeability, and inflammation. We hypothesized that fingolimod has a positive effect on alleviating preterm fetal brain injury.