Fingolimod against endotoxin-induced fetal brain injury in a rat model

YAVUZ A., SEZİK M., Ozmen O., AŞCI H.

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, cilt.43, sa.11, ss.1708-1713, 2017 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 43 Sayı: 11
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1111/jog.13444
  • Dergi Adı: JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1708-1713
  • Anahtar Kelimeler: endotoxin, fetal brain injury, fingolimod, neuroprotection, preterm birth, PRETERM, PREGNANCY, INFECTION, PREVENTS, PROTECTS, FTY720, BIRTH
  • Süleyman Demirel Üniversitesi Adresli: Evet

Özet

AimFingolimod is a sphingosine-1-phosphate receptor modulator used for multiple sclerosis treatment and acts on cellular processes such as apoptosis, endothelial permeability, and inflammation. We hypothesized that fingolimod has a positive effect on alleviating preterm fetal brain injury.