Fingolimod against endotoxin-induced fetal brain injury in a rat model

YAVUZ A., SEZİK M., Ozmen O., AŞCI H.

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, vol.43, no.11, pp.1708-1713, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 43 Issue: 11
  • Publication Date: 2017
  • Doi Number: 10.1111/jog.13444
  • Journal Name: JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1708-1713
  • Keywords: endotoxin, fetal brain injury, fingolimod, neuroprotection, preterm birth, PRETERM, PREGNANCY, INFECTION, PREVENTS, PROTECTS, FTY720, BIRTH
  • Süleyman Demirel University Affiliated: Yes

Abstract

AimFingolimod is a sphingosine-1-phosphate receptor modulator used for multiple sclerosis treatment and acts on cellular processes such as apoptosis, endothelial permeability, and inflammation. We hypothesized that fingolimod has a positive effect on alleviating preterm fetal brain injury.