Estimation of thermodynamic acidity constants of some penicillinase-resistant penicillins


Demiralay E. C. , ÜSTÜN Z. , Daldal Y. D.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, cilt.91, ss.7-11, 2014 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 91
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.jpba.2013.12.008
  • Dergi Adı: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
  • Sayfa Sayıları: ss.7-11

Özet

In this work, thermodynamic acidity constants ((s)(s)pK(a)) of methicillin, oxacillin, nafcillin, cloxacilin, dicloxacillin were determined with reverse phase liquid chromatographic method (RPLC) by taking into account the effect of the activity coefficients in hydro-organic water-acetonitrile binary mixtures. From these values, thermodynamic aqueous acidity constants of these drugs were calculated by different approaches. The linear relationships established between retention factors of the species and the polarity parameter of the mobile phase (E-T(N)) was proved to predict accurately retention in LC as a function of the acetonitrile content (38%, 40% and 42%, v/v). (C) 2013 Elsevier B.V. All rights reserved.