The effects of the ethanol extract of Cordia myxa leaves on the cognitive function in mice


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KENDİR G., Bae H. J. , Kim J., Jeong Y., Bae H. J. , Park K., ...More

BMC COMPLEMENTARY MEDICINE AND THERAPIES, vol.22, no.1, 2022 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 1
  • Publication Date: 2022
  • Doi Number: 10.1186/s12906-022-03693-z
  • Journal Name: BMC COMPLEMENTARY MEDICINE AND THERAPIES
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Keywords: Cordia myxa, Alzheimer's disease, Recognition memory, Sensorimotor gating, PI3K-Akt-GSK3 beta signaling, ERK-CREB signaling, ROSMARINIC ACID, ALZHEIMERS-DISEASE, MEDICINAL-PLANTS, MEMORY DEFICITS, IMPAIRMENT, RECEPTOR, ANTIOXIDANT, INHIBITION, INFECTION, L.

Abstract

Background: Cordia myxa L. (Boraginaceae) is widely distributed in tropical regions and it's fruits, leaves and stem bark have been utilized in folk medicine for treating trypanosomiasis caused by Trypanosoma cruzi. A populationbased study showed that T. cruzi infection is associated with cognitive impairments. Therefore, if C. myxa has ameliorating activities on cognitive function, it would be useful for both T. cruzi infection and cognitive impairments.