Evaluation of preventive effect of shilajit on radiation-induced apoptosis on ovaries
ARCHIVES OF GYNECOLOGY AND OBSTETRICS, cilt.293, sa.6, ss.1255-1262, 2016 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 293 Sayı: 6
- Basım Tarihi: 2016
- Doi Numarası: 10.1007/s00404-015-3924-6
- Dergi Adı: ARCHIVES OF GYNECOLOGY AND OBSTETRICS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1255-1262
- Süleyman Demirel Üniversitesi Adresli: Hayır
Özet
Canc er is the second leading cause of death in children in developed countries and most of childhood malignancies can be treated with chemo-radiotherapy. Although radiation therapy is a successful treatment modality in cancer patients, it has various adverse effects. Especially the gonads are very sensitive and prone to radiation-related damage. Radiation impairs the ovaries by triggering apoptosis of follicular cells and chromosomal damage and oxidative stress. Shilajit, a traditional medicinal agent in India, Russia, and other parts of the world, contains various antioxidant agents and has ovogenic effects. To evaluate the ability of shilajit to prevent radiation-induced ovarian damage.