Evaluation of preventive effect of shilajit on radiation-induced apoptosis on ovaries


Kececi M., Akpolat M., Gulle K., Gencer E., Sahbaz A.

ARCHIVES OF GYNECOLOGY AND OBSTETRICS, cilt.293, ss.1255-1262, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 293 Konu: 6
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1007/s00404-015-3924-6
  • Dergi Adı: ARCHIVES OF GYNECOLOGY AND OBSTETRICS
  • Sayfa Sayıları: ss.1255-1262

Özet

Canc er is the second leading cause of death in children in developed countries and most of childhood malignancies can be treated with chemo-radiotherapy. Although radiation therapy is a successful treatment modality in cancer patients, it has various adverse effects. Especially the gonads are very sensitive and prone to radiation-related damage. Radiation impairs the ovaries by triggering apoptosis of follicular cells and chromosomal damage and oxidative stress. Shilajit, a traditional medicinal agent in India, Russia, and other parts of the world, contains various antioxidant agents and has ovogenic effects. To evaluate the ability of shilajit to prevent radiation-induced ovarian damage.