Evaluation of preventive effect of shilajit on radiation-induced apoptosis on ovaries

Kececi M., Akpolat M., Gulle K., Gencer E., Sahbaz A.

ARCHIVES OF GYNECOLOGY AND OBSTETRICS, vol.293, no.6, pp.1255-1262, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 293 Issue: 6
  • Publication Date: 2016
  • Doi Number: 10.1007/s00404-015-3924-6
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1255-1262
  • Süleyman Demirel University Affiliated: No


Canc er is the second leading cause of death in children in developed countries and most of childhood malignancies can be treated with chemo-radiotherapy. Although radiation therapy is a successful treatment modality in cancer patients, it has various adverse effects. Especially the gonads are very sensitive and prone to radiation-related damage. Radiation impairs the ovaries by triggering apoptosis of follicular cells and chromosomal damage and oxidative stress. Shilajit, a traditional medicinal agent in India, Russia, and other parts of the world, contains various antioxidant agents and has ovogenic effects. To evaluate the ability of shilajit to prevent radiation-induced ovarian damage.